On October 22-23, 2025 a planning committee of the National Academies of Sciences, Engineering, and Medicine will convene a two-day hybrid public workshop to explore “make, buy, and invest” strategic actions to strengthen the resiliency of the U.S. pharmaceutical supply chain. “Make” strategies involve shifting pharmaceutical production to domestic manufacturers, “buy” strategies involve rewarding global manufacturers with good manufacturing practices, and “invest” strategies involve shifting pharmaceutical production from countries with higher supply chain risks to countries and regions with stronger reliability and established partnerships. The workshop will explore:
- identification of key drugs and markets that could benefit the most from strategic actions;
- consideration of potential opportunities and barriers; and
- essential steps for implementation of strategic actions (including core needs and associated costs).
The workshop discussions will advance understanding of the challenges and opportunities associated with make-buy-invest strategies to develop solutions to drug shortages and enhance the resilience of the US pharmaceutical supply chain against shocks and stressors from major events (i.e., health emergencies, natural disasters, conflicts) and other key global strategic concerns. A proceedings of a Workshop–in Brief will be prepared by a designated rapporteur.